MAIC analysis of influenza host factors

MAIC results for host genes implicated in influenza virus replication. See the full table of data sources.

This circular graph is a representation of the shared information content between each data source after MAIC. Size of data source blocks is proportional to information content – i.e. the total MAIC scores contributed by each data source. Lines showing shared information content are colored according to the dominant data source.

Data Sources

Data sources for Meta-Analysis by Information Content (MAIC)

Sources of data used for MAIC. Where possible, data were obtained from the comprehensive meta-analysis by Tripathi et al1. Genome-wide screens were limited to a maximum of 2000 genes. Lists of “hits” identified by the authors of some screens using a variety of combinatorial statistical methods, were included as unranked lists, as in Tripathi et al1. FANTOM5 coexpression clusters (C270, C413, C3829, C3538, C0, C527, C1236, C1162, C4341, C2, C13, C1932, C6, C26, C447, C7, C187, C884, C2568, C3953, C2409) were included if they were associated with influenza in the original FANTOM5 paper.2 Each gene derives only one MAIC score from a given data source category (See Methods, main paper).
Category Datasource Type Ref
CRISPR_survival Han_RD2 Ranked 3
CRISPR_survival Han_RD5 Ranked 3
RNAi Tripathi_Z_RSA Ranked 1
RNAi S4_host_Z_Konig Ranked 1,4
RNAi S4_host_Z_Karlas Ranked 1,5
RNAi S4_host_Z_Brass Ranked 1,6
RNAi S4_host_Z_Ward Ranked 1,7
RNAi_confirmed S4_host_SuHit Ranked 8
RNAi_confirmed S4_host_TranHit Ranked 9
RNAi_confirmed S4_host_ShapiraHit Ranked 10
RNAi_confirmed Kawaoka_knockdown_restricts_top Ranked 11
RNAi_confirmed Kawaoka_knockdown_restricts Ranked 11
RNAi_drosophila Hao_DOWN Ranked 12
shRNA Hacohen_lentivirus_shRNA Ranked
Annotated KEGG(174) Not ranked 13
Annotated FluMap_Kawaoka Not ranked 14
HaploidScreen Carette Not ranked 15
Positive_selection SabetiOver125 Ranked 16
Genetic CiancelliHorby Not ranked 17,18
protein_interaction S4_host_Viral_ShapiraY2H Not ranked 10
protein_interaction deChassey_y2h Not ranked 19
APMS S4_host_Viral_APMS Not ranked 1
COIP WatanabeCOIP Not ranked 11
COIP S4_host_COIP_Tripathi Not ranked 1
incorporated Hutchinson_incorporated Not ranked 20
protein_interaction Song_et_al Ranked 21
protein_interaction Shaw_et_al Not ranked 22
protein_interaction Tafforeau Ranked 23
protein_interaction Bradel-Trethaway Ranked 24
protein_interaction Heaton Ranked 25
protein_interaction Jorba Ranked 26
protein_interaction Lin Ranked 27
Proteomics Dove_Increased2fold Ranked 28
Proteomics Dove_Decreased2fold Ranked 28
expression Shapira_expression(1028) Not ranked 10
coexpresssion FANTOM5 coexpression clusters associated with influenza Not ranked 2

References

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